Replace your in vitro blood brain barrier screen with a low cost, high throughput ex vivo screen
EntomoPharm provides robust ex vivo data from cutting-edge insect models for pre-clinical ADMET testing with high throughput and no need for expensive re-synthesis.
The EntomoPharm core services on blood brain barrier permeability are based on measuring brain uptake into whole locust brains. The derived data can be used for ranking small-molecule compounds to identify drug leads with improved BBB permeability properties. The models can replace standard early screen cascade, e.g. cell based systems, and can serve as an efficient filter for decision-making on which compounds to progress further to full-blown preclinical in vivo studies in rodents. There is an additional opportunity for assessing the impact of P-glycoprotein (P-gp) efflux since the studies are performed in whole brains, complete with a functional BBB.
We are confident in the quality and inherent advantages of our models and hence we are willing to offer all new customers the opportunity to try our services with an introductory pilot study.
For more information about Entomopharm and/or the introductory pilot study please click on the links below: